Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. PLoSone 2011, 11:e27547. You are using an out of date browser. Acta Endocrinol 1988, 118:460464. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? Just for entertainment value take a look at some more dodgy correlations : I rather liked the correlation between consumption of orange marmalade and birth rate - in the years after the second world war if I remember correctly. Millions Treated for Hypothyroidism at Risk for Lung Cancer It took over five years before the someone figured out my ongoing symptoms were due to hypothyroidism. View the data on GreenMedInfos Hypothyroidism Research page. J Exp Biol 2010, 213:28992911. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. Hypothyroidism (underactive thyroid) - Diagnosis and treatment - Mayo The study included more than 128,000 veterans aged 18 to 26 and found that, just 30.2% of females and 18.7% of males had received HPV vaccination. Sayer Ji is the founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, and SteeringCommittee Memberof the Global Non-GMO Foundation. weight loss, anorexia). " Sub-laboratory hypothyroidism and the empirical use of Armour thyroid. Kelly Mellott on LinkedIn: Nodify Lung: Nodule Risk Assessment | Biodesix Symptoms. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab. 2002 Feb ;25(2):106-9. Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM. At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. Patients with incomplete information (n = 127), preexisting hypothyroidism or levothyroxine replacement before initiation of ICI therapy (n = 11), or other factors known to contribute to thyroid dysfunction after immunotherapy (n = 17) were excluded (Fig. [learn more: Is Drug-Based Medicine a Form of Human Sacrifice?] If you are already a member, please, Levothyroxine and lung cancer in females: the importance of oxidative stress, recent announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs. Capmatinib (Tabrecta) is the first FDA-approved MET-targeting medication for treating metastatic NSCLC. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. Symptoms can include fatigue, shortness of breath with exercise, and decreased ability to exercise. As a person with Graves Disease, I underwent 6 cycles of radio-ablation using i 131 to 'fry' my thyroid gland as surgery was deemed too risky due to the vascularity and size of my gland. Is Drug-Based Medicine a Form of Human Sacrifice? This discussion has been closed to comments. Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. Brit Med J 1978, 1:210212. Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new disease case the patient is converted into a lifelong customer. LifeGivingStore.comRed Light Therapy - Hydrogen Water Generators - Cascara Sagrada - Vitamins, Minerals & Amino Acid Supplements - Cocoa Products - Handcrafted Soaps - Grass Fed Organs & Glandulars - Nano Soma. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to replacement therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. Ultimately, this latest Italian study is bringing to our attention one of what is likely a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. radioactive treatments. Not what people like me are saying. [12] Cesarone MR, Belcaro G, Nicolaides AN, Incandela L, De Sanctis MT, Barsotti A: San Valentino epidemiologic project. I am going to go for a walk with my dog :)). Brit Med J 1978, 1:210212. It does not seem to quantify the increased risk, and it keeps saying it is hyperthyroidism that causes the oxidised stress. For a better experience, please enable JavaScript in your browser before proceeding. Nanosized aluminum being sprayed in the atmosphere CDC Admits as Many as 30 Million Americans Could b Why Turmeric May Be the Diseased Liver's Best Friend. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. It is worth reading. JavaScript is disabled. Importance: Whether radioactive iodine (RAI) therapy for hyperthyroidism can increase cancer risk remains a controversial issue in medicine and public health. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. Currently, the best practical approach is to base treatment decisions on the degree of TSH elevation, thyroid autoimmunity, and associated comorbidities. Hypothyroidism: symptoms, causes, treatment, medicine, prevention elevated TSH, without actually improving the overall physiological situation, nor the patient's subjective experience of well being. The first blood test typically done to diagnose hypothyroidism measures the level of thyroid-stimulating hormone (TSH) in the blood. J Endocrinol Invest. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as "hypothyroidism"? Perhaps she and I could co-author? In fact, it is the high levels of T4 that make them more susceptible to cancer. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. However, they pointed out that the opposite was actually described, and that hypothyroidism reduces the aggressiveness of some cancers because of the presence of thyroid hormone receptors on cancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers.[1]. This is a news report of the research, so I can't learn the details of how the science was conducted. Tokushima J Exp Med 1991, 38:2535. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. If it's high, the test is done again, along with a blood test for the thyroid hormone T-4. Medical Authoritys System Kills: FDA-Approved Dru Cognitive Impairment, Memory Loss and Alzheimer's Soy Lecithin: How It Negatively Affects Your Healt Cannabis Oil Cures Cancer -Lincoln Horsley's Story New Information Dissolves Illusions About Vaccines Grounding Helps Thin Dangerously Thick Blood and F Tart Cherries Relieve Osteoarthritis Pain, Lieberman's Massive Connections To Big Pharma, Utopian 'Harvest Your Own' Groceries Coming Up. Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new 'disease' case the patient is converted into a lifelong customer. Note: Only a member of this blog may post a comment. A distorted idea of human nature is sold when people are treated as "the market. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. 1 The number of individuals with thyroid disorders is expected to continue to grow, having reached approximately 750 million globally in 2012. It may not display this or other websites correctly. Millions Treated For Hypothyroidism At Risk For Lung Cancer Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low . However, I do not believe it was out of the blue now. As I am the caregiver for my dad who has Stage IV lung Cancer, I hope more research can be done on this topic soon. [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. She wrote about a product called Thyrtophin PMG. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. For more, visitGreenMedInfo.comand Facebook.com/GreenMedInfo, or sign up forGreenMedInfos free e-Newsletter. The Remarkable Heart-Friendy Properties of Avocados. I think there is always a lot of confusion with cause and cure. "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)", International Journal of Human Nutrition and Functional Medicine, Osteoporosis Is Scurvy of the Bone, Not Calcium Deficiency, 6 Bodily Tissues That Can Be Regenerated Through Nutrition, 7 Simple Ways to Unclog Your Arteries Naturally, Herbal Cream Clears 87.7% of HPV Cases Naturally, How WHOLE Turmeric Heals the Damaged Brain. [4] Ratcliffe JG, Stack BH, Burt RW, Radcliffe WA, Spilg WG, Cuthbert J, Kennedy RS: Thyroid function in lung cancer. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Sin un requerimiento, el cumplimiento voluntario por parte de tu Proveedor de servicios de Internet, o los registros adicionales de un tercero, la informacin almacenada o recuperada slo para este propsito no se puede utilizar para identificarte. I hope that with increased knowledge we will all find the right road. Even in the mildest form, hypothyroidism affects the heart. Endocrinology 1985, 117:12011208. In comparison, 62.4% of female and 37% of male . Based just on this article, I think the study's conclusion that Synthroid may cause an increase in lung cancer risk is premature. Methods: The study group included 35 patients (15 women, 20 men, 65.8 7.1 years) with NSCLC in stage IIIB (n = 16, 45.7%) and IV (n = 19,54.3%) who were treated with nivolumab. Why not simply call it selenium deficiency? Increased sensitivity to cold. In the U.S., the overall five-year survival rate for patients diagnosed with lung cancer is 25%, which is a 21% improvement over the . It's usually based on the results of blood tests. I invite those interested to read it and perhaps we can have a discussion on this study. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. Also this study finds no link with breast cancer, when others have found a link. PMID: 11929079, [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. Non-small cell lung cancer is the most common type of lung cancer, accounting for about 81% of all cases. This website is for information purposes only. El almacenamiento o acceso tcnico es estrictamente necesario para el propsito legtimo de permitir el uso de un servicio especfico explcitamente solicitado por el abonado o usuario, o con el nico propsito de llevar a cabo la transmisin de una comunicacin a travs de una red de comunicaciones electrnicas. Endocrinology 2008, 149:22412250. I very much appreciate the information you shared. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. Breast cancer has surpassed lung cancer as the most commonly diagnosed cancer worldwide, according to GLOBOCAN. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. I have posted the link now. Is so taking anti oxidants might be an idea. Due to excessive bot signups along with nefarious actors we are limiting forum registration. Millions of people who were not only wrongly diagnosed with 'cancers' and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. The authors expanded on their findings further: However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. Angiology 2000, 51:S65S68. Monaldi Arch Chest Dis 2003, 59:140145. Endocrinology 1985, 117:12011208. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. There are several books out there written about the topic. [3] Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. Data sources: The Medline and Cochrane Library electronic databases . Just go on one of the thyroid sites and read the stories. Levothyroxine and cancer risk study : Hi sorry to - Thyroid UK [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. Targeted therapy for lung cancer: Side effects and more millions treated for hypothyroidism at risk for lung cancer In addition, untreated hypothyroidism is associated with a gradual decline in cognitive function and memory. However, they pointed out that the opposite was recently described, and that "hypothyroidism reduces theaggressiveness of some cancers because of the presence of thyroid hormone receptors oncancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness ofcancers."[1]. PLoSone 2011, 11:e27547. Log In. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. Hypothyroidism can cause depression and, without treatment, the symptoms intensify and directly affect the mental state. So I will leave it as a simple thank you for passing this along. I have so much to say about this I could write a book. Cancer-related fatigue (CRF) is common in lung cancer survivors and can occur at any point in the care continuum. I was sure that the paper had been discussed here shortly after publication in 2013, but cannot find the thread! Diagnosed 1/12 with lung cancer out of the blue. Once I got on the medication, the symptoms disappeared. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. But that's just me. I had doctor after doctor tell me it was in my head or I was menopausal. [5] Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5' deiodinase in lung cancer with peripheral lung tissues. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. In 2011 I switched docs and was put on Armour as he told me Synthroid and the like are poison and they do not work. Maybe because they "treat" only with T4 and not T3? millions treated for hypothyroidism at risk for lung cancer. However, that information will still be included in details such as numbers of replies. I don't think so. rocket fuel, pesticides, fluoride, which induce low thyroid function. The great open sky of imagination: for those who u Fermented Foods: Top 8 Reasons to Eat Them. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. An Italian study published in the journalReproductive Biology and Endocrinology,titled Levothyroxine and lung cancer in females: the importance of oxidative stress, has raised a concerning possibility: levothyroxine (T4), one of the worlds most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). SayerJiis founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, SteeringCommittee Memberof the Global Non-GMO Foundation. Increased sleepiness. That's all. arizona lockdown status today; tiktok unblocked from school; samantha and savannah concepcion Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. Privacy Policy. U.S. FDA Broadens Indication for Verzenio (abemaciclib) in HR+, HER2 I have posted the link, so you can see if it has any merit. Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called active ingredient T4 versus the natural variations in hormone concentrations found in the real thing, which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. With the recent announcement by a National Cancer Institute commissioned expert panel that a variety of so-called 'indolent' neoplasms such as ductal carcinoma in situ (DCIS) and high-grade prostatic intraepithelial neoplasia (HGPIN), formerly understood to be forms of breast and prostate cancers, respectively, should be renamed to reflect their intrinsic benignity, a veritable sea change is occurring within the conventional medical establishment. I have been reading Izabella Wentz. En 3 minutos recibirs en tu email COMPLETAMENTE GRATIS todo lo que necesitas para aumentar las ventas de tu empresa. The Goji Berry: The Jolly Super Food That Gives Yo How to Prevent and Treat Insect Bites Without Hars Supreme Court Rules Drug Companies Exempt From Law Spain Study Confirms Hemp Oil Cures Cancer without Wheatgrass Turns Gray Hair Back to Its Natural Color, Medicinal Cannabis Used To Prevent Cancer Growth. Endocrinology 2008, 149:22412250. Thank you for posting it, I agree we all need as much knowledge as we can get! However, I'm learning from science writer friends, researchers, and medical professionals that (1) some studies are better designed and carried out than others, and (2) some journalists are more careful about drawing conclusions and writing sensational headlines than others.